What if Lyme disease is only part of the story? In this fascinating conversation, Dr. Richard Horowitz and Dr. Daniel Amen explore Lyme disease, chronic inflammation, immune dysfunction, and the complex symptoms that can persist long after an initial infection. Why can Lyme be so difficult to diagnose and treat? How might inflammation affect the brain and body? And what can we learn from looking at chronic illness through both an infectious-disease and brain-health lens? This is a wide-ranging conversation about Lyme disease, inflammation, the immune system, brain health, and the search for answers when conventional explanations fall short.